Advanced Technologies Center: plans and innovations
The companies "Advanced Technologies Center" and "Energy Efficient Technologies" were included in the rating of the most high-tech and innovative companies "TechUspekh" following the results of 2019. The TechUspekh rating is a tool for searching, monitoring and promoting of the promising fast-growing technology companies that have high leadership potential both in the Russian and global markets.
The group of companies "Advanced Technologies Center" and "Energy Efficient Technologies" has several main promising areas: biosensors for molecular diagnostics, scanning probe microscopy, scanning capillary microscopy, 3D printing, machining centers and development of software for processing data in microscopy. All these areas have grown on the basis of the existing competence to create atomic force microscopes of the Scan and FemtoScan series .
FemtoScan Online software is successfully used for data processing in microscopy, for example, in electron, probe and any other microscopy, not only in Russia but also abroad [2, 3, 4, 5].
Based on a capillary microscope, we are developing 3D bioprinting. Printing is carried out by biomacromolecules and biological objects: DNA, RNA, proteins, lipids, viruses and virus-like particles. The results obtained are in demand, in particular, in biosensor applications in the manufacture of microchips and sensors, localized immobilization of bioprobes on a substrate to prevent steric restrictions during hybridization of the target with probes. Electrochemical control of ion fluxes allows of highly localized delivery of precursor particles and at the same time maintains a dynamic feedback on the change in ion current to fix a given distance from the probe to the substrate. This is necessary for the formation of high-quality patterns using biomacromolecules. A 30–50 nm diameter capillary tip for each channel makes it possible to produce structures of various shapes with a high aspect ratio – L/d, where L is the length of the capillary, d is the average diameter. This approach provides versatility and reliability of the scanning and printing method in nanoscales with high spatial resolution. A scanning capillary microscope allows tracking the relief of an uneven and rough surface, allows you to modify and add the required properties to complex three-dimensional surfaces. Such surfaces can be lipid and other biological membranes, bacterial biofilms, cell surfaces and living tissues. For control purposes, methods of transmission and scanning electron microscopy, fluorescence optical microscopy, mass spectrometry, piezoceramic weighing, atomic balance, etc. are used. Despite the apparent complexity, anyone can enroll for a capillary microscopy course through the Nanotechnology YICC. Created with the support of the Advanced Technologies Creativity Center and the Moscow Government on the basis of the Physical Department of Moscow State University, YICC Nanotechnology celebrates its 6th anniversary this year. In December 2019, Nanotechnology YICC took part in the congress "Science + Business", organized by the Innopraktika Foundation. At the event, the ATC Industry 4.0 computer numerical center developed with the support of the FASIE [6,7] was presented.
The key features of the ATC Industry 4.0 Machining Center are:
availability of the automatic tool change;
high speed spindle;
corrugated protection along all axes;
small dimensions and weight;
attractive price for a machining center with an automatic tool change – 1,150,000 rubles.
A general view of the milling processing center with an automatic tool change is shown in Fig.3.
The "Nanotechnology" YICC regularly conducts training courses in the field of physical engineering.
3D design in SolidWorks and machining. The goal of the program is design training in the SolidWorks program. Students will learn how to build 3D parts, assemble units and constructions, develop design documentation, and choose various strategies for processing materials. As part of the course, students work with universal software for controlling CNC machines.
Scanning probe microscopy. The course presents a wide range of equipment, training programs and presentations for the experimental study of bionanoscopy. Students will learn how to use the FemtoScan scanning probe microscope, as well as the FemtoScan Online software. To pass the final certification, it is proposed to scan a sample and process the resulting image.
Detailed information about the courses can be found on the website of the Physical Department of Moscow State University in the section of supplementary education – http://dopobr.phys.msu.tilda.ws/page1745646.html
Information on all the developments of the Advanced Technologies Center and Energy Efficient Technologies companies is publicly available on www.nanoscopy.ru and www.2ETechnologies.com. ■
The work on the manufacturing of the machining center was carried out with the support of the FASIE, Contract No. 422GRNTIS5/44715. Research on capillary microscopy was carried out with the financial support of the Russian Foundation for Basic Research in the framework of the scientific project No. 17-52-560001. The authors express their sincere gratitude to the Department of Entrepreneurship and Innovative Development of the City of Moscow and the Ministry of Economic Development of the Russian Federation (Agreement No. 8/3-63in-16 dated 08.22.16) for their support of the YICC Nanotechnology.