DOI: https://doi.org/10.22184/1993-8578.2025.18.3-4.166.172

An innovative biocompatible multielectrode cell integrating neuronal electrical activity recording technologies with high-resolution scanning capillary microscopy capabilities has been developed and characterized. The proposed design includes an ITO-coated glass substrate with laser-patterned electrodes insulated with a 180 nm thick parylene layer and functionalized copper-gold microelectrodes with memristor properties. The prototype demonstrates the advantages of simultaneous recording of neuronal electrical activity and morphological changes, opening up new possibilities for studying neuronal plasticity, structural distribution of nervous tissue, and screening of neuroactive compounds.