DOI: https://doi.org/10.22184/1993-8578.2025.18.6.336.344

Atomic force microscopy allows high-resolution visualization of enveloped viruses, which include viruses of the Coronaviridae family, to study the nature of their adsorption on various surfaces, to measure the mechanical properties of viruses, to assess the effect of changes in the environment and temperature on morphology. Using force curves, it is possible to calculate the Young’s modulus of a viral particle, to assess the nature of the interaction between the envelope protein and the cellular receptor, and even to measure the strength of this interaction. All these capabilities not only allow us to characterize viruses, but also help prevent the spread of pathogens in the human population and choose the optimal treatment strategy.